Wiss was last seen leaving an apartment complex in the 500 block of Marion Road in Wichita, Kansas on January 11, 2000. Her friend told authorities that she saw Wiss heading towards Pawnee Street and Broadway Street between 10:00 and 10:30 p.m. that evening. Investigators believe that Wiss may have had her pager, apartment keys and wallet with her when she disappeared. She has never been heard from again.

Wiss was scheduled to testify in a felony statutory rape trial two days after her disappearance. Her mother stated she was unhappy about having to testify, but had agreed to do so. Authorities do not know if her disappearance is connected to the trial or if other factors are involved in her case.

Wiss was initially classified as a runaway, but investigators have since stated that she vanished under unclear circumstances. She left behind all her clothes, and her Social Security number has not been used since she went missing. Her mother stated that prior to her disappearance, she had often spoken of wanting to go to California. Wiss was living with a friend of her mother's at the time of her disappearance; she wanted to experiment with living away from home. Her case remains unsolved.